Prevent the visible signs of aging 1  

What is RADIESSE®?

RADIESSE® is the next step in collagen boosting treatments for skin renewal. It is a a one-of-a kind treatment 1 that works to regenerate and restore the natural components of your skin foundation for more youthful-looking, firmer skin1. By stimulating the production of collagen and elastin, together with key components of the skin helps to give structure and support to sagging skin and helps smooth out wrinkles.2,3


Collagen is the key in skin aging

When speaking about skin aging, we are actually talking about the process of collagen loss. When we are young, collagen is organized in a dense network that keeps our skin firm, smooth and radiant. Over time, the network loosens and the impulse to produce more collagen decreases. As a result, you begin to see the common signs of aging – such as skin laxity and wrinkles.4,5

How RADIESSE® works

RADIESSE® is composed of a defined range of tiny microspheres of calcium hydroxylapatite (CaHA) suspended in a gel. The CaHA microspheres create scaffolds that stimulate the body’s natural processes to produce new collagen and elastin. Over time, your body dissolves these tiny microspheres and the gel, leaving behind only your own newly formed natural collagen.6-12

Leaving your skin regenerated with an improvement in skin quality, contour and structure depending on the treatment.1 For immediate and long-lasting, natural-looking results for 12-18 months or more.13,14


Personalized treatment options

RADIESSE® is a one-of-a kind regenerative biostimulator 1,6-8 with a uniquely designed formulation and technology offering you an individualized treatment approach – tailored to your unique needs.6,7,15

  • Improves skin quality2,13
  • Shape and redefine facial contours5
  • Supports against sagging for a lifted, youthful appearance*1,16

* “Healthy-looking skin” is defined by regeneration of collagen I and III, elastin, proteoglycans, and angiogenesis.

This is the RADIESSE® treatment procedure

RADIESSE® is injected under the skin in the targeted area(s). The amount of RADIESSE® injected will influence the treatment time, but typically a consultation including treatment lasts around 30 minutes.6

Before / After

Visible results with RADIESSE®

RADIESSE® can be used in a variety of indications and treatment areas, offering versatility to provide a wide range of personalized treatments.6,7

Choose the different treatment sections through the drop down menu and drag the slider over the image to see the results of the treatment.


Age of Patient: 45 years old

Product & treatment

Patient injected with RADIESSE® (+) in the cheeks and the jawline.

Individual results may vary, please ask your doctor for consultation. The after photo was taken 14 days after the treatment. No picture retouching has been done.

Key Facts about RADIESSE®

  • Collagen boosting. Invest in your skin with this foundational treatment which acts at the source to boost collagen and reverse signs of aging.15
  • Long-lasting renewal. Targeted collagen and elastin production for renewing healthy skin** tissue for more than 12 months.17
  • Formulated with naturally occuring ingredients. Formulated with naturally occuring ingredients. Purposely designed with components that occur naturally in the body.6,18
  • Minimally invasive with a well-established clinical safety profile. With little to no downtime.6,17
  • Available in over 85 countries worldwide19
  • 15 million syringes shipped-world wide19

** “Healthy skin” is defined by regeneration of collagen I and III, elastin, proteoglycans, and angiogenesis.


Frequently Asked Questions

Depending on the treatment performed, the effect can be visible immediately after injection due to the immediate enhancement effect. Additionally, by stimulating your body’s own natural collagen production, the benefits of lifting, contour and / or skin quality improvement with RADIESSE® continue to develop over time.13,17

The duration of the results depends on many individual characteristics such as age, skin profile, lifestyle, metabolism, and of course, the area treated. RADIESSE® results are normally durable, and lasting up to 12 to 18 months based on clinical data.17,20

RADIESSE® is a minimally invasive treatment with high patient satisfaction, clinically proven in a vast number of studies.10,21 It requires little to no downtime. You can usually resume your normal activities immediately after the procedure.

It is important to look for a clinic or practitioner who is well-trained in the handling of injectables and experienced in the use of the collagen biostimulator RADIESSE®. More than 15 million patients have been treated with RADIESSE® and benefited from its well-established and favorable safety profile based on scientific and clinical experiences as shown in various studies.9,17,19

Clinic Finder

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Here you will find experts who can consult you on the benefits you can achieve from Merz Aesthetics® products.

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  1. Kim, J. Clin Cosmet Investig Dermatol. 2019;(12;):771–784.
  2. González, N, Goldberg, DJ. Dermatol Surg. 2019;(45):547–551.
  3. Courderot-Masuyer, C, et al. J Cosmet Dermatol. 2016;(15):260–268.
  4. Fisher GJ, et al. Arch Dermatol. 2008 May;144(5):666-72.
  5. Varani J, et al. Am J Pathol. 2006 Jun;168(6):1861-8.
  6. RADIESSE®. Instructions for Use.
  7. RADIESSE®(+). Instructions for Use.
  8. Bagnenko E.S., Povzun S.A. Anisomorphism of calcium hydroxylapatite particles in fillers as a potential factor of unstable treatment outcomes: electron microscopic study. Injection methods in cosmetology, No. 2 (2018) 46-50).
  9. Kadouch JA. J Cosmet Dermatol. 2017;16(2):152-161.
  10. Moers-Carpi, M. et al. Dermatol Surg 2007;33(Suppl 2):S144–151.
  11. Pavicic T. J Drugs Dermatol. 2013 Sep;12(9):996-1002.
  12. Tzikas TL. Dermatol Surg. 2008;34 Suppl 1:S9-15.
  13. Yutskovskaya Y, et al. J Drugs Dermatol. 2014 Sep;13(9):1047-52.
  14. Marmur ES, et al. J Cosmet Laser Ther 2004;6:223–6.
  15. Wollina U, et al. Dermatol Ther. 2020;33(6):e14183.
  16. Nowag, B. Presented at Aesthetic and Anti-Aging Medicine World Congress;2019.
  17. Loghem JV, et al. J Clin Aesthet Dermatol. 2015;8(1):38-49.
  18. Draoui O, van Loghem J, Peeters WJ, Siebenga P. Chapter 1: RADIESSE® – The story of calcium hydroxylapatite. In: van Loghem J, ed. Calcium Hydroxylapatite Soft Tissue Fillers, Expert Treatment Techniques. 1st ed. Taylor & Francis Group. 2021.
  19. Merz Aesthetics®. Data on File.
  20. Bass LS, Smith S, Busso M, McClaren M. Aesthetic Surgery J. 2010; 30(2):235-238.
  21. Muti GF. J Drugs Dermatol. 2019;18(1):86-91.