Inspired by Nature
Biomimetic by Design
BELOTERO® delivers results so natural, they’re biomimetic1-3
Discover a portfolio of biomimetic hyaluronic acid (HA) treatments, each precisely engineered for seamless integration at a specific tissue depth—whether the goal is refining moderate lines, restoring midface volume, or sculpting and enhancing lips.1-5
Why hyaluronic acid is key to a youthful appearance
The natural aging process of the skin can be accelerated by UV radiation, facial expressions, lack of sleep, hormonal changes and unhealthy diets.6-9 However, even the healthiest lifestyle cannot stop the natural aging process.
This is a result of the skin producing less of its own moisture regulators over time, such as hyaluronic acid – a natural component of connective tissue.10,11 Over time, cells divide more slowly and the concentration of water and fat decreases. As a result, the skin becomes thinner and drier, losing elasticity, volume and contour. Through its ability to bind water, hyaluronic acid cushions the skin together, promoting its elasticity and firmness.
The BELOTERO® collection of premium hyaluronic acid fillers, offers a variety of dermal fillers with different concentrations of hyaluronic acid that are intentionally designed for different treatment outcomes and areas of the face.4,5,12
Reasons to choose BELOTERO®,
the Biomimetic HA filler collection
BIOMIMETIC FILLER POWERED BY UNIQUE CPM TECHNOLOGY
+ First and only biomimetic HA treatment using the unique CPM technology2,13
+ High- and low-density zones to mimic characteristics and behaviour of human skin2
+ Seamless tissue integration allowing for natural-looking, harmonious and long-lasting results*2,4,5,12,14,15
COMPREHENSIVE COLLECTION FOR TAILORED SOLUTIONS
+ Versatile collection allowing for the treatment of a wide range of indications4,5,12
+ Natural-looking results across many facial areas4,5,12
+ Treatment adaptable to patients’ unique needs and wishes2,16
EVIDENCE-BASED RESULTS
+ High patient satisfaction14,15
+ Well-established safety profile14,15,17
+ 150+ peer-reviewed publications18
+ 21+ million syringes shipped19
+ 20+ years of clinical use18
*Results last from 3 months to 18 months, based on product used and area treated.2,4,5,12,14,15
One technology. Precise products. Intelligent integration.
The BELOTERO® portfolio is built on a single, proprietary Cohesive Polydensified Matrix (CPM)® technology,1 engineered to mimic skin’s natural structure at different depths.1-3 Choose the right product to meet your patients’ goals.
The restorer designed with high plasticity, elasticity, and viscosity for ideal reshaping with volume enhancement5
Treats: cheeks, midface5
LASTS UP TO 18 MONTHS20
The sculptor designed with high elasticity and viscosity for lip augmentation12
Treats: nasolabial folds, marionette lines, lips12
LASTS UP TO 12 MONTHS21
The refiner designed with balanced elasticity and viscosity for refinement and filling of lines and wrinkles (including around the mouth)4
Treats: nasolabial folds, infraorbital hollows, perioral lines, horizontal forehead lines4
LASTS UP TO 18 MONTHS22**
**Among patients who were responders at Week 8 (n=22), 90.2% (20/22) retained treatment response up to 72 weeks after the last injection.22
Introducing two new indications in the BELOTERO® collection
BELOTERO® BALANCE is now approved for the treatment of: Infraorbital Hollows (including tear throughs) and Horizontal Forehead Lines.
Visible results with BELOTERO®
Drag the slider over the image to see the effect of the BELOTERO® treatment. You can choose the different treatment sections through the drop down menu.
Patient concern
This patient was unhappy with the wrinkles that had formed over the years around her lips. She also noticed a loss of volume around her midface.
Product & treatment
Patient got injected with BELOTERO® BALANCE Lidocaine, BELOTERO® VOLUME Lidocaine and BELOTERO® LIPS Shape.
The photos shown are taken 14 days after treatment.
Treatment areas
Lips and cheeks.
No picture retouching has been done. Individual results may vary, please ask your doctor for consultation.
Instructions for Use
- Tran C, et al. Dermatology. 2014;228(1):47-54.
- Casabona G, et al. Dermatol Surg.Published online May 15, 2026. doi:10.1097/DSS.0000000000005152
- Hermitte L, Benoit O, inventors; Anteis SA, assignee. Biocompatible crosslinked gel. US patent 8,052,990. November 8, 2011.
- BELOTERO Balance (+) [Instructions for Use]. IN00201-01. Merz North America, Inc; 2023.
- BELOTERO Volume (+) [Prescribing Information and Instructions for Use]. IN00241-00. Merz North America, Inc; 2026.
- Anson G, et al. Aesthet Surg J 2016;36: 931–940.
- Dunn JH, Koo J. Dermatol Online J 2013;19:18561.
- Oyetakin-White P, et al. Clin Exp Dermatol 2015;40:17–22.
- Vashi NA, et al. J Clin Aesthet Dermatol 2016;9:31–38.
- Gomi T, Imamura T. Int J Cosmet Sci 2020;42:359–368.
- Papakonstantinou E, et al. Dermatoendocrinol 2012;4: 253–258.
- Belotero Intense (+) [Prescribing Information and Instructions for Use]. IN00262-00. Merz North America, Inc; 2026.
- Patent Note: WO 2005/085329 “Biocompatiple crosslinked gel.”
- Kerscher M, et al. Facial S. Plastic and Reconstructive Surgery–Global Open. 2021;9(12):e3973.
- Kühne U, et al. Clin Cosmet Investig Dermatol. 2016;9:373–81.
- Suwanchida A, et al. J Cosmet Dermatol. 2026;25:e70784.
- Vandeputte J. J Clin Aesthet Dermatol. 2018;11:30–39.
- Merz Aesthetics. Data on File. 2025.
- Merz Aesthetics. Data on File. 2026.
- Micheels P, et al. J Clin Aesthet Dermatol.2015;8(3):28-34.
- Gerber PA, et al. Aesthet Surg J Open Forum.2026;8:ojag031.
- Biesman BS, et al. Aesthet Surg J.2024;44(9):976-986.